Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide. Schizophrenia diagnosis is associated with more than double the all-cause mortality risk of the general population and a 13- to 15-year reduction in life expectancy, due to a myriad of intersecting factors and underlying causes. Persons with schizophrenia are particularly susceptible to the negative health effects of extreme heat, as demonstrated by the 2021 Western North America Heat Dome. During this event, schizophrenia was associated with a 3-fold increase in the odds of mortality in British Columbia, Canada, far surpassing the risks associated with other common heat-sensitive chronic conditions, including diabetes, hypertension, and heart disease. While individual factors such as age, presence of chronic disease, and medication-use can impair thermoregulation and limit a person's ability to sense and respond to heat, physiological and behavioural factors associated with schizophrenia can exacerbate these impairments. In-turn, social and community-level factors play important roles in aggravating or mitigating heat-health risks. However, to date, our understanding of the separate and combined influence of the physiological, behavioural, and social determinants underpinning heat-susceptibility in individuals with schizophrenia remains largely unresolved. We therefore conducted a critical review to examine the physiological factors that can increase susceptibility to the negative effects of heat in persons with schizophrenia and profile the social and community-level factors aggravating or mitigating these risks. An interdisciplinary, multi-level approach is essential to facilitate effective heat-health planning and community adaptation to prevent heat-related injuries and deaths in persons with schizophrenia during extreme heat.